Signatures of Natural Selection on Mutations of Residues with Multiple Posttranslational Modifications
نویسندگان
چکیده
منابع مشابه
Signatures of natural selection on mutations of residues with multiple posttranslational modifications.
Posttranslational modifications (PTMs) regulate molecular structures and functions of proteins by covalently binding to amino acids. Hundreds of thousands of PTMs have been reported for the human proteome, with multiple PTMs known to affect tens of thousands of lysine (K) residues. Our molecular evolutionary analyses show that K residues with multiple PTMs exhibit greater conservation than thos...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2014
ISSN: 0737-4038,1537-1719
DOI: 10.1093/molbev/msu137